Forschungsgebiete Statistik und Datenanalyse Populationsgenetik Biomathematik Malariagenetik COVID-19 SARS-CoV-2 Ebola Malaria
Projektleitung Beobachtung von antimikrobieller Resistenz und Diagnoseeffizient von Malaria in Indischen Stammesgebieten zur Erreichung von Ausrottungszielen - AREMD, Teilvorhaben: methodische Neuentwicklung und statistische Auswertungen finanziert durch Bundesministerium für Bildung und Forschung 2020 - 2023 Innovationsvorhaben zur Profilschärfung 2022, AP 4.12 Wissenschafts-Praxis-Transfer in der Epidemiologie von Malaria finanziert durch Sächsisches Staatsministerium für Wissenschaft, Kultur und Tourismus 2022 Hochschulkooperationen AIMS in Südafrika, Kamerun & Ghana 2018-2022: Mathematics against malaria within the AIMS network finanziert durch Deutscher Akademischer Austauschdienst 2018 - 2022 Ökologisch nachhaltige Wertschöpfungsketten in der Landwirtschaft durch Optimierung des Insektizid-Gebrauchs aufgrund von automatisiertem Schädlings-Monitoring finanziert durch Deutsche Forschungsgemeinschaft 2019 - 2022 Vorlaufforschung Technologieentwicklung 4.0, AP 8 finanziert durch Sächsisches Staatsministerium für Wissenschaft, Kultur und Tourismus 2019 - 2021 Innovationscluster HSMW 2021, AP 9-04: Forschungsanschub zur Steigerung der Drittmittelfähigkeit der Hochschule 2021 Innovationscluster HSMW 2021, AP 9-05: Forschungsanschub zur Steigerung der Drittmittelfähigkeit der Hochschule 2021 Vorlaufforschung Technologieentwicklung 4.0 2019 - 2021 Verbundprojekt Erschließung von mobilen Sensordaten für die Publikumsforschung durch interaktive Lernverfahren (AGILE), Teilprojekt: Empirische Netzwerkforschung finanziert durch Europäische Union 2017 - 2020 Innovationsvorhaben Profilschärfung an Hochschulen für angewandte Wissenschaften, AP 6: Statistische Verfahren und Mathematische Modelle zur Analyse von genetischen Daten mit Anwendung auf Malaria finanziert durch Sächsisches Staatsministerium für Wissenschaft, Kultur und Tourismus 2016 - 2018 Entwicklung und Demonstration der Verwendbarkeit eines Erfassungssystems für Publikumsströme 2 (Flowbile) 2015 - 2017 Weiterentwicklung Flowbile-Recorder 2016 Forschungs- und Entwicklungsvorhaben zur Publikumslenkung im regionalen Personen-Nahverkehr, Teilvorhaben 1: Flowbile - Mittweidas digitaler Bewegungsmelder 2015
ausgewählte Publikationen Journalartikel A maximum-likelihood method to estimate haplotype frequencies and prevalence alongside multiplicity of infection from SNP data. Frontiers in Epidemiology. 2022 Complement component 3 mutations alter the longitudinal risk of pediatric malaria and severe malarial anemia. Experimental Biology and Medicine. 672-682. 2022 Does it matter who is spreading monkeypox?. The Lancet Infectious Diseases. 2022 Elevated SARS-CoV-2 in peripheral blood and increased COVID-19 severity in American Indians/Alaska Natives. Experimental Biology and Medicine. 1253-1263. 2022 Evolutionary genetics of malaria. Frontiers in Genetics. 2022 Genetic variation in CSF2 (5q31.1) is associated with longitudinal susceptibility to pediatric malaria, severe malarial anemia, and all-cause mortality in a high-burden malaria and HIV region of Kenya. Tropical Medicine and Health. 41. 2022 Investigating the impact of multiple feeding attempts on mosquito dynamics via mathematical models. Mathematical Biosciences. 108832. 2022 Nonsynonymous amino acid changes in the α-chain of complement component 5 influence longitudinal susceptibility to Plasmodium falciparum infections and severe malarial anemia in kenyan children. Frontiers in Genetics. 2022 Reconsidering the incubation period of Marburg virus disease. The Lancet Infectious Diseases. 1525-1526. 2022 Screening of potential antiplasmodial agents targeting cysteine protease-Falcipain 2: a computational pipeline. Journal of Biomolecular Structure and Dynamics. 1-44. 2022 The many definitions of multiplicity of infection. Frontiers in Epidemiology. 2022 Yes, it matters who is spreading monkeypox – Authors' reply. The Lancet Infectious Diseases. 1417. 2022 An integrated virtual screening and drug repurposing strategy for the discovery of new antimalarial drugs against Plasmodium falciparum phosphatidylinositol 3‐kinase. Journal of Cellular Biochemistry. 1326-1336. 2021 Bias-corrected maximum-likelihood estimation of multiplicity of infection and lineage frequencies. PLOS ONE. e0261889. 2021 Differential Gene Expression in Host Ubiquitination Processes in Childhood Malarial Anemia. Frontiers in Genetics. 2021 Is increased mortality by multiple exposures to COVID-19 an overseen factor when aiming for herd immunity?. PLOS ONE. e0253758. 2021 Preventing COVID-19 spread in closed facilities by regular testing of employees – an efficient intervention in long-term care facilities and prisons. medRxiv. 2021 Preventing COVID-19 spread in closed facilities by regular testing of employees—An efficient intervention in long-term care facilities and prisons?. PLOS ONE. e0249588. 2021 The impact of COVID-19 vaccination campaigns accounting for antibody-dependent enhancement. PLOS ONE. e0245417. 2021 Is increased mortality by multiple exposures to COVID-19 an overseen factor when aiming for herd immunity?. medRxiv. 2020 Changes in the frequencies of Plasmodium falciparum dhps and dhfr drug-resistant mutations in children from Western Kenya from 2005 to 2018: the rise of Pfdhps S436H. Malaria Journal. 378. 2020 Malaria in Venezuela: changes in the complexity of infection reflects the increment in transmission intensity. Malaria Journal. 176. 2020 The COVID-19 pandemic preparedness simulation tool: CovidSIM. BMC Infectious Diseases. 859. 2020 Limited differentiation among Plasmodium vivax populations from the northwest and to the south Pacific Coast of Colombia: A malaria corridor?. PLOS Neglected Tropical Diseases. e0007310. 2019 Correction: A Likelihood Approach to Estimate the Number of Co-Infections. PLOS ONE. e0192877. 2018 Large and finite sample properties of a maximum-likelihood estimator for multiplicity of infection. PLOS ONE. e0194148. 2018 Profiles of low complexity regions in Apicomplexa. BMC Evolutionary Biology. 47. 2016 Persistence of Sulfadoxine-Pyrimethamine Resistance Despite Reduction of Drug Pressure in Malawi. Journal of Infectious Diseases. 694-701. 2015 A Likelihood Approach to Estimate the Number of Co-Infections. PLOS ONE. e97899. 2014 A Population Genetic Model for the Initial Spread of Partially Resistant Malaria Parasites under Anti-Malarial Combination Therapy and Weak Intrahost Competition. PLOS ONE. e101601. 2014 Fitness components and natural selection: why are there different patterns on the emergence of drug resistance in Plasmodium falciparum and Plasmodium vivax?. Malaria Journal. 15. 2013 Genetic Hitchhiking under Heterogeneous Spatial Selection Pressures. PLOS ONE. e61742. 2013 The Hitchhiking Effect of a Strongly Selected Substitution in Male Germline on Neutral Polymorphism in a Monogamy Population. PLOS ONE. e71497. 2013 Differences in selective pressure on dhps and dhfr drug resistant mutations in western Kenya. Malaria Journal. 77. 2012 Local population structure of Plasmodium: impact on malaria control and elimination. Malaria Journal. 412. 2012 Approximations for the hitchhiking effect caused by the evolution of antimalarial-drug resistance. Journal of Mathematical Biology. 789-832. 2011 Evolution of Assortative Mating in a Population Expressing Dominance. PLOS ONE. e16821. 2011 An analytical model for genetic hitchhiking in the evolution of antimalarial drug resistance. Theoretical Population Biology. 93-108. 2010 EVOLUTION OF DOMINANCE UNDER FREQUENCY-DEPENDENT INTRASPECIFIC COMPETITION IN AN ASSORTATIVELY MATING POPULATION. Evolution. 561-582. 2010 Maximization principles for frequency-dependent selection II: the one-locus multiallele case. Journal of Mathematical Biology. 95-132. 2010 Generalized Hankel operators on the Fock space. Mathematische Nachrichten. 1811-1826. 2009 Optimization under frequency-dependent selection. Theoretical Population Biology. 1-12. 2009 Maximization principles for frequency-dependent selection I: the one-locus two-allele case. Theoretical Population Biology. 251-262. 2008 Long-term evolution of polygenic traits under frequency-dependent intraspecific competition. Theoretical Population Biology. 342-366. 2007 A multilocus-multiallele analysis of frequency-dependent selection induced by intraspecific competition. Journal of Mathematical Biology. 483-523. 2006 Intraspecific Competitive Divergence and Convergence under Assortative Mating. The American Naturalist. 190-205. 2006 THE CONDITIONS FOR SPECIATION THROUGH INTRASPECIFIC COMPETITION. Evolution. 2185-2206. 2006 Competitive divergence in non-random mating populations. Theoretical Population Biology. 105-118. 2005 Konferenzpaper You can’t drive my car - a method to fingerprint individual driving styles in a sim-racing setting. 2022 International Conference on Electrical, Computer and Energy Technologies (ICECET). 2022 Konferenzposter 564 Sustaining Ebola Management By Predictive Modeling 2020 Estimating Multiplicity of Infection, allele Frequencies and Prevalences from incomplete data 2020 Estimating haplotype frequencies alongside multiplicity of infection from malaria SNPs data 2020 Make diversity measure great 2020 Mathematical modelling of Anopheles mosquito breeding site for efficient vector control 2020 Mechanisms driving the spread of HRP2/3 deletions -a modeling approach 2020 Protecting people in long-term care facilities from COVID-19 by routine testing of employees - a modeling approach 2020 Protecting people in long-term care facilities from COVID-19 by routine testing of employees - a modelling approach 2020 The spread of drug resistance in P. vivax vs. P.falciparum malaria – the effect of hypnozoites 2020 Meeting Abstract Complement component 5 (C5) missense mutations alter the longitudinal risk of pediatric malaria and severe malarial anemia. Scientific Reports 2021, International Week 2021. 32-33. 2021 Diversity measures. Scientific Reports 2021, International Week 2021. 32-32. 2021 The IRESSEF – an institution conducting public health research in Senegal. Scientific Reports 2021, International Week 2021. 31-32. 2021 Preprint Predicting the combined effects of case isolation, safe funeral practices, and contact tracing during Ebola virus disease outbreaks. medRxiv. 2022 Predicting the impact of COVID-19 vaccination campaigns – a flexible age-dependent, spatially-stratified predictive model, accounting for multiple viral variants and vaccines. medRxiv. 2022 Sammelbandbeitrag COVID-19 research at HSMW. Scientific Reports 2021, International Week 2021. 23-25. 2021 Charles Darwin Meets Ronald Ross: A Population-Genetic Framework for the Evolutionary Dynamics of Malaria. Infectious Diseases and Our Planet. 149-191. 2021 European-African Partnership Lessons Learned. Scientific Reports 2021, International Week 2021. 3-6. 2021 Sustaining Ebola management by predictive modelling. Scientific Reports 2021, International Week 2021. 16-19. 2021 The International Collaboration of Math Against Malaria. Scientific Reports 2021, International Week 2021. 20-22. 2021 Measuring diversity among competing supply-value chains. Sustainability in Global Value Chains - Measures, Ethics and Best Practices for Responsible Businesses. Hrsg. Henke, Michael. 106-128. 2020
Präsentationen auf Veranstaltungen Fächerübergreifend, ModeratorIn, während Jahrestagung für ausländische Stipendiaten Hanns-Seidel-Stiftung 2016 Tropenmedizin und Malariaforschung, ModeratorIn, während 65th Annual Meeting of the American Society for Tropical Medicine & Hygiene 2016 Populationsgenetik, ModeratorIn, während Annual Retreat of Vienna Graduate School of Population genetics 2016 A maximum-likelihood approach to estimate the number of co-infections in malaria, vortragende Person, während Big Data: mathematical methods and applied problems 2015
Mitwirkung in einer Organisation Vienna Graduate School of Population Genetics Assoziiertes Mitglied 2015 -
betreut/e wissenschaftliche Arbeit Masterarbeit A maximum likelihood estimation of multiplicity of infection (MOI) from molecular data collected by routine screening 2015 Promotion Mathematische Modelle zur Prognose von Medikamentenresistenz bearbeitet durch Hashemi Eshkiki, Meraj 2016 -